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Major Autohemotherapy (MAH)

This therapy requires that about 60cc of blood be removed from the body. It is mixed with saline and then ozone gas is bubbled into the mixture. Finally, it is dripped back into the patient. Ozone gas, (‘O3’) is made from oxygen gas (‘O2’) when the addition of energy allows for three oxygen atoms to bind together instead of the usual two. Ozone is unstable so it breaks down quickly back to O2 and the third oxygen molecule bonds to various biological molecules, forming ozonides. Biological tissues exposed to ozonides utilize more oxygen, which means they make more ATP, the energy currency of the cell. Cells can make energy using oxygen and creating carbon dioxide in a process called oxidative phosphorylation. This process is complicated and slow but yields a lot of energy. They can also make it the quick and dirty way, called glycolysis, which yields lactic acid and only 6% as much energy. It seems that inflamed, diseased or dysfunctional tissues have a tendency to favor glycolysis. By causing them to use more oxidative phosphorylation, ozone therapy appears to make more energy available to sick cells. MAH is often combined with UV Blood Irradiation or UVBI.

Major Autohemotherapy (MAH)

The cost is $140.40.


The Sound Clinic offers two different methods of systemic ozone administration. The more common of the two is called Major Autohemotherapy (MAH). The newer version goes by several names including Ozone High-Dose Therapy (OHT), Hyperbaric Ozone Therapy (HBO3 or HBO3T), or simply ‘10-pass’ ozone therapy. This is best described as a more potent variation of MAH. Both procedures involve removing of blood from the body, ozonating it, and then returning it to circulation.

We have been pleased overall with the results of MAH, but also feel that it is often impractical and/or not economical to complete number of treatments necessary to maximize the therapeutic potential of the modality. The OHT machine is able to overcome this limitation because it makes it possible to deliver much more ozone to the blood in a given amount of time. It creates a vacuum that facilitates blood extraction and pressure that expedites the re-infusion of ozonated blood. The pressure that it can generate also creates a hyperbaric effect that enhances ozone delivery to the blood.

We estimate that an OHT treatment (in which about 2L of blood is ozonated over the course of up to ten consecutive 200cc ‘passes,’ delivers 30-60 times as much ozone as a single MAH treatment. Treatments last about 90 minutes on average. Some clinics routinely administer 10 passes daily for weeks but we usually recommend just one treatment per week for 4 to 8 consecutive weeks.

To our knowledge, there is no head-to-head data comparing MAH to OHT. Since ozone isn’t patentable, there’s little money for research and, accordingly, we don’t expect there to be any serious scientific publications in the foreseeable future. But it stands to reason that treatment benefits achieved through the use of MAH should be attainable more quickly and/or after fewer treatments using OHT. Since little is known about the ‘ceiling’ of benefit from the medical use of ozone, it’s likely that OHT is capable of delivering outcomes that MAH cannot.

A collection of articles on the medical use of ozone is available from http://www.zotero.org/groups/isco3_ozone. The leading proponent for OHT in the United States in Robert Rowen, MD. We’re not sure he’s an ideal ambassador but some patients may find postings on his YouTube channel to be informative.

Refer to American Academy of Ozonotherapy for more information.

Ozone Article

MAH Consent

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